### Understanding Primary Hyperoxaluria Type 1 (PH1) Primary Hyperoxaluria Type 1 (PH1) is a rare genetic disorder that affects the kidneys and other parts of the body. People with PH1 often have kidney-related problems, but the disease can present with a variety of symptoms that differ from person to person. #### Symptoms in Babies and Young Children - **Failure to Thrive**: Babies may be smaller in height and weight for their age. - **High Oxalate Levels**: High levels of oxalate in urine can be detected during doctor’s appointments. - **Painful Stones**: Stones in kidneys, bladders, or urethras can cause pain. - **Kidney Damage**: Gradual kidney damage from oxalate crystals can lead to kidney failure. #### Symptoms in Older Children and Teens - **Kidney or Urinary Stones**: Frequent stones can occur. - **Bedwetting**: Younger children may wet the bed or have difficulty controlling urination. - **Worsening Kidney Damage**: Over time, kidney damage can lead to kidney failure. #### Symptoms in Adults - **Recurrent Kidney Stones**: Adults may repeatedly have kidney stones. - **Kidney Failure**: Blockages caused by stones can lead to kidney failure. - **Milder Form**: Symptoms appearing in adulthood are often milder, but kidney disease or failure can still occur. #### Complications - **Kidney Failure**: As the disease progresses, kidney failure can occur. - **Oxalosis**: Oxalate can build up in other parts of the body, causing hard crystal deposits that damage organs and tissues. This can lead to serious symptoms. Early diagnosis and treatment are crucial to managing PH1 and preventing severe complications. If you suspect any symptoms, consult a healthcare professional for proper evaluation and care.