### What Causes Painful or Itchy Blisters in the Mouth and How to Treat Them? Painful or itchy blisters in the mouth can be caused by a group of diseases known as autoimmune blistering disorders. These disorders occur when the immune system mistakenly attacks the skin and mucous membranes, including the lining inside the mouth. This results in the formation of blisters. There are several types of autoimmune blistering disorders, including: - **Pemphigus**: Causes blisters on the skin and inside the mouth, nose, throat, eyes, and genitals. - **Pemphigoid**: Has three main types and also causes blisters. - **IgA mediated bullous dermatoses**: The immune system produces a lot of immunoglobulin A (IgA), leading to blisters. - **Epidermolysis bullosa acquisita**: Mostly affects middle-aged and older adults, causing fragile skin that blisters easily. The blisters can be painful or itchy and may break open, leaving sores. The exact cause of these disorders is unknown, but genetic factors and certain triggers like medications can play a role. Treatment focuses on managing symptoms and preventing complications. This may include: - **Medications**: To lower the immune system response and prevent it from attacking the skin and mucous membranes. - **Topical treatments**: To soothe and protect the affected areas. - **Antibiotics**: To prevent infections if blisters break open. - **Proper care**: Keeping blisters clean and avoiding popping them to prevent scars and infections. Each person's condition is different, so it's important to work with a doctor to find the most effective treatment plan.