### Managing Side Effects of Extended-Release Injectable Naltrexone (Vivitrol) Extended-release naltrexone (Vivitrol) can cause side effects, but they are usually mild and temporary. Here’s how to manage them: **Injection Site Reactions:** - Pain and tenderness are common. Ice the area and take over-the-counter pain relievers like ibuprofen. - A small lump may appear but should go away in 2-4 weeks. Contact your doctor if it becomes painful, red, or swollen. **Nausea and Vomiting:** - Rest and avoid strong odors. Stay hydrated with cold, clear drinks and eat bland foods. - Over-the-counter motion sickness medications can help. **Headache:** - Rest and take pain relievers like aspirin or ibuprofen. **Dizziness:** - Move slowly when standing up. Drink fluids but avoid caffeine and tobacco. **Sleepiness:** - Avoid driving or operating machinery. Take short naps and get some exercise. **Decreased Appetite:** - Eat small, regular meals with high-protein, vitamin-rich foods. Try liquid meals like smoothies. **Joint Pain or Muscle Cramps:** - Take pain relievers and use ice or heat. Stretch and massage the area. **Cold Symptoms:** - Drink liquids, use a humidifier, and try saline nasal rinses. Over-the-counter medications can help. **Serious Side Effects:** - **Opioid Overdose:** Inform close ones to call 911 if you show signs of overdose. - **Sudden Opioid Withdrawal:** Seek immediate medical help if symptoms are severe. - **Liver Damage or Hepatitis:** Contact your doctor if you notice signs of liver issues. - **Depression:** Watch for signs and contact your doctor. In emergencies, dial 988 for the Suicide and Crisis Lifeline. - **Pneumonia:** Seek medical help if you have persistent shortness of breath, wheezing, or coughing. - **Serious Allergic Reactions:** Get immediate medical help for severe skin rash, trouble breathing, or swelling. Always consult your doctor for personalized advice and treatment options.