### How Nurtec ODT Treats and Prevents Migraines Nurtec ODT is a medication that dissolves in your mouth to treat and prevent migraines. It belongs to a class of drugs called CGRP antagonists. CGRP is a protein that can cause blood vessels to widen, leading to pain and inflammation during a migraine. Nurtec ODT blocks CGRP from binding to its receptors, helping to relieve pain and prevent future migraines. #### How to Use Nurtec ODT - **For Acute Migraine:** Take one 75-milligram tablet as needed. Do not take more than one tablet in 24 hours. - **For Prevention:** Take one tablet every other day. Keep the tablet in its blister pack until you are ready to take it. Use dry hands to open the pack and place the tablet on or under your tongue to let it dissolve without water. Do not push the tablet through the foil. #### Clinical Studies Two studies showed that Nurtec ODT is effective for treating and preventing migraines. In one study, 21% of people were pain-free 2 hours after taking Nurtec, compared to 11% with a placebo. In another study, people taking Nurtec had 4.3 fewer migraine days per month compared to 3.5 days with a placebo. #### Side Effects Common side effects include nausea, stomach pain, and upset stomach. If you experience severe allergic reactions like trouble breathing or a severe rash, stop taking Nurtec and seek medical help immediately. #### Interactions Certain medications and grapefruit juice can affect how Nurtec works. Inform your healthcare provider about all the medicines and supplements you are taking. Nurtec ODT requires a prescription and may be available at a reduced cost with a copay card from the manufacturer. Consult your healthcare provider for more information.