### How Zavzpret Nasal Spray Treats Migraines Zavzpret is a nasal spray approved in 2023 for treating acute migraine attacks. It contains an active ingredient called zavegepant, which is a CGRP antagonist. CGRP is a protein that can cause blood vessels to widen, leading to pain and inflammation during a migraine. By blocking CGRP, Zavzpret helps relieve pain. #### How to Use Zavzpret - **Dosage**: Use a single 10-milligram spray in one nostril as needed. Do not use more than one spray in 24 hours or more than eight doses in 30 days. - **Preparation**: Keep Zavzpret in its blister pack until ready to use. Do not test spray or prime the device. - **Application**: Blow your nose, press one nostril closed, and insert the device into the open nostril. Keep your head level and breathe in slowly while pressing the plunger. - **Post-application**: Breathe in through your nose and out through your mouth for 10-20 seconds. If medicine drips out, gently sniff. Dispose of the device after use. #### Effectiveness Studies show that Zavzpret can provide relief within 2 hours, with some people remaining pain-free for up to 48 hours. However, results may vary. #### Side Effects Common side effects include an unusual taste, nausea, nasal discomfort, and vomiting. Severe allergic reactions are rare but require immediate medical attention. #### Interactions Avoid using nasal spray decongestants with Zavzpret. Inform your healthcare provider about all medications and supplements you are taking. #### Prescription and Cost Zavzpret requires a prescription and is available at pharmacies. A copay card may reduce the cost to $0, depending on your insurance. For more information, visit the drugmaker’s website or consult your healthcare provider.