If your psoriatic arthritis (PsA) hasn't responded to initial treatments, your doctor might suggest trying monoclonal antibodies, a type of biologic drug. These drugs help by calming down the immune system but only target specific parts of it. This helps reduce inflammation in both the skin and joints caused by PsA. Monoclonal antibodies work by blocking certain proteins called cytokines that cause inflammation. There are two main types: TNF inhibitors and interleukin inhibitors. TNF inhibitors have been around longer and are usually tried first. If they don't work, doctors may switch to interleukin inhibitors. These drugs are usually given through self-injection or an IV infusion. While effective, they can have side effects like headaches, infections, and mild allergic reactions. It's important to get tested for infections like hepatitis B and tuberculosis before starting treatment. Regular doctor visits are needed to manage side effects and ensure the treatment is working.