### Common and Serious Side Effects of Cabotegravir (Apretude) for PrEP **Common Side Effects:** 1. **Injection Site Reactions:** Up to 80% of people experience pain, redness, or swelling where the shot is given. These usually go away within a week. 2. **Upset Stomach:** Symptoms like nausea can be managed by drinking extra fluids and eating bland foods like crackers and bananas. 3. **Headache:** Rest, ice packs, or over-the-counter pain relievers can help. Consult your doctor if it persists. 4. **Flu-like Symptoms:** Fatigue and slight fever may occur. Over-the-counter pain relievers can help, but inform your doctor. 5. **Sleep Trouble:** Establish a regular sleep schedule and avoid caffeine and electronics before bed. 6. **Weight Gain:** Some people gain 4-9 pounds over two years. Diet and exercise adjustments may help. **Serious Side Effects:** 1. **Severe Allergic Reactions:** Symptoms include rash, itching, and difficulty breathing. Seek immediate medical help. 2. **Liver Damage:** Symptoms include yellowing of the skin or eyes, dark urine, and severe stomach pain. Regular liver function tests are recommended. 3. **Mood Changes:** Symptoms of depression may occur. Consult your doctor if you experience mood changes. If you experience any severe side effects, contact your healthcare provider immediately.