### Symptoms of Lyme Disease The first sign of Lyme disease is often a bull's-eye rash. This rash appears as a red spot surrounded by a clear area with a red outer ring. Along with the rash, you might experience flu-like symptoms such as fatigue, headache, fever, sore throat, chills, or body aches. If the infection is not treated with antibiotics, it can lead to more severe symptoms. These can include joint pain, especially in the knees, stiff neck, sensitivity to light, memory loss, mood changes, recurring rashes, and even paralysis of one or both sides of the face. Other serious symptoms can involve heart rhythm problems and areas of tingling or numbness. Early detection and treatment are crucial to prevent these severe complications. If you notice a bull's-eye rash or sudden knee pain and swelling without injury, seek medical attention promptly.