### Understanding Eosinophilic Esophagitis (EoE) and Its Diagnosis Eosinophilic esophagitis (EoE) is a condition where a type of white blood cell called eosinophils builds up in the esophagus, causing inflammation and difficulty in swallowing. Symptoms include trouble swallowing, chest pain, food getting stuck in the throat, and chronic issues with the esophagus. EoE is more common in males, particularly white men in their 20s and 30s. Diagnosing EoE can be challenging because its symptoms are similar to other conditions like GERD (gastroesophageal reflux disease) and PPI-REE (proton pump inhibitor-responsive esophageal eosinophilia). GERD is caused by acid reflux and can lead to similar symptoms, while PPI-REE responds to proton pump inhibitors, unlike typical EoE. To diagnose EoE, doctors may conduct allergy tests to check for reactions to foods, pollen, mold, animal dander, or dust mites. Family history can also be a factor. Treatment options include PPIs, elimination diets, and swallowed topical steroids. Recently, the FDA approved Dupilumab (Dupixent) for EoE, which targets the immune system and has shown promise in reducing symptoms and improving tissue condition. Originally developed for atopic dermatitis (eczema), Dupilumab is also used for asthma and nasal polyps. It can be prescribed to adults and children aged 12 and up.###