Psoriasis is a chronic skin condition that can be managed with various treatments. Recent advancements have introduced new medications that target specific parts of the immune system. These are known as biologics. Biologics are made from substances found in living organisms and are designed to block certain immune system components that contribute to psoriasis. They are usually injected into the skin or bloodstream. Some of the FDA-approved biologics for moderate to severe psoriasis include drugs that interfere with TNF-alpha, T cells, or interleukins, which help reduce inflammation and the growth of thick, scaly skin. While biologics are effective, they can be expensive and may increase the risk of infections and other complications. Doctors also recommend lifestyle changes such as maintaining a healthy weight, exercising, and following a diet that reduces inflammation. The Mediterranean diet, rich in fish, fruits, vegetables, nuts, and olive oil, is often suggested. Weight loss can also improve psoriasis symptoms and enhance the effectiveness of medications. Researchers are also exploring the role of the gut microbiome and probiotics in managing psoriasis. Overall, a combination of medication, lifestyle changes, and ongoing research offers hope for better management of psoriasis.