What are the potential benefits and risks of using vitamins and supplements like folic acid, fish oil, selenium, and vitamin D for managing moderate to severe psoriasis?

### Potential Benefits and Risks of Psoriasis Supplements **Fish Oil**: Rich in omega-3 fatty acids, fish oil may help reduce inflammation associated with psoriasis. Some studies show it can improve symptoms like redness, itching, and scaling. However, results are mixed, and high doses can cause side effects like bad breath, heartburn, and nausea. It may also interact with certain medications. **Vitamin D**: This nutrient, available through sunlight, food, and supplements, may help reduce inflammation in psoriasis. Topical creams with vitamin D are generally safe and can be effective. High doses of oral vitamin D have shown promise in small studies but need more research. Overdosing can lead to side effects like nausea and kidney stones. **Folic Acid**: Known as vitamin B9, folic acid may help reduce inflammation in psoriasis. Some studies suggest it can improve symptoms, especially in people with low homocysteine levels. However, evidence is limited, and it can interact with medications like methotrexate. **Selenium**: This trace mineral may help reduce inflammation and calm the immune system. Some studies show it can improve psoriasis symptoms when combined with other supplements. However, high doses can cause side effects like hair loss and nausea. **Shark Cartilage**: Believed to slow the growth of blood vessels feeding psoriasis lesions, shark cartilage has limited evidence supporting its effectiveness. Some studies show mild improvements, but it can interact with other medications and potentially worsen symptoms. Always consult with a dermatologist before starting any new supplement to ensure it’s safe and won’t interfere with other treatments.