Connective tissue diseases are a group of disorders that affect the tissues supporting organs and other parts of the body. These tissues include fat, bone, and cartilage. These diseases often involve the joints, muscles, and skin, but can also affect other organs like the eyes, heart, lungs, kidneys, gastrointestinal tract, and blood vessels. There are over 200 types of connective tissue diseases. Some are caused by genetic changes, while others may be triggered by environmental factors in genetically susceptible individuals. Here are some common types: **Ehlers-Danlos Syndrome (EDS)**: This group of over 10 disorders is characterized by overly flexible joints, stretchy skin, and abnormal scar tissue growth. Symptoms range from mild to disabling. **Epidermolysis Bullosa (EB)**: People with EB have extremely fragile skin that tears or blisters easily. Some forms may affect the digestive tract, respiratory tract, muscles, or bladder. **Marfan Syndrome**: This affects bones, ligaments, eyes, heart, and blood vessels. People with Marfan syndrome are usually tall with long bones and thin fingers and toes. **Osteogenesis Imperfecta**: Known for brittle bones, low muscle mass, and loose joints. Symptoms vary depending on the type. **Polymyositis and Dermatomyositis**: These involve muscle inflammation (polymyositis) and skin inflammation (dermatomyositis). **Rheumatoid Arthritis (RA)**: An autoimmune disease where the immune system attacks the joints, causing pain, stiffness, and swelling. **Scleroderma**: Causes thick, tight skin and can lead to organ damage. **Sjögren's Syndrome**: The immune system attacks moisture-producing glands, causing dry eyes and mouth, fatigue, and joint pain. **Systemic Lupus Erythematosus (SLE)**: Causes inflammation of the joints, skin, and internal organs. **Vasculitis**: Involves inflammation of blood vessels, affecting blood flow to organs and tissues. **Mixed Connective Tissue Disease (MCTD)**: Features of several diseases like lupus, scleroderma, and rheumatoid arthritis. Symptoms can range from mild to severe. Early diagnosis and treatment are crucial for managing these diseases.