When atopic dermatitis (also known as eczema) is mild, you can often control it with over-the-counter moisturizers and bathing. A topical steroid ointment can help when your skin flares up. However, for moderate to severe cases, these simple steps may not be enough. Treating severe atopic dermatitis can be challenging, but there are more options available now than before. For moderate to severe atopic dermatitis, you’ll likely need medication to keep it under control. Doctors usually start with topical medicines like corticosteroids, calcineurin inhibitors, phosphodiesterase 4 inhibitors, JAK inhibitors, and coal tar. If your skin has an infection, your doctor might prescribe an antibiotic cream or oral antibiotics. If these treatments aren't enough, other options include light therapy and systemic medications. Light therapy, or phototherapy, is often recommended when topical treatments fail. Narrowband ultraviolet B is a common type used. You might need it two or three times a week, and it can dry out your skin, so ask your doctor if you need extra moisturizer. Long-term phototherapy can increase the risk of skin cancer and may be costly. Immunosuppressants can also help, but doctors now often prefer biologics like dupilumab and tralokinumab-ldrm, which are generally safer for long-term use. Dupilumab is given as shots every two weeks, while tralokinumab-ldrm works differently and is also administered as a shot. JAK inhibitors like abrocitinib and upadacitinib are another option if other treatments fail. Basic skin care remains important even with medication. Regular baths or showers and using a good moisturizer can help manage symptoms. Mental health is also crucial, as stress and anxiety can trigger flares. Consider talking to a therapist or counselor. Each person’s atopic dermatitis is different, so work with your doctor to develop a personalized treatment plan. While you might not completely eliminate symptoms, a combination of approaches can help manage the condition.