### Biologic Drugs for Treating Crohn's Disease Biologics are prescription drugs made from living organisms. They are often prescribed when other treatments haven’t worked. These drugs target specific proteins in your body that cause inflammation, helping to manage symptoms of Crohn’s disease. #### Types of Biologics Approved by the FDA 1. **TNF-alpha Inhibitors**: These drugs target a protein called TNF-alpha that is part of the inflammation process. Examples include: - Adalimumab - Adalimumab-adbm - Adalimumab-atto - Certolizumab - Infliximab - Infliximab-abda - Infliximab-dyyb 2. **Integrin Inhibitors**: These drugs stop certain molecules in your immune system called integrins from attaching to other cells in the lining of your intestines. Examples include: - Natalizumab - Vedolizumab 3. **Interleukin Inhibitors**: These drugs block proteins like interleukin 12 and 23, which are part of the inflammation process. Examples include: - Ustekinumab - Risankizumab #### How They Are Given - **Shots**: Some biologics are given as shots under your skin every 2 to 8 weeks. - **IV Infusions**: Others are administered through an IV. The schedule may vary, but often includes an initial dose followed by maintenance doses every few weeks. #### Common Side Effects - Infections like tuberculosis and sepsis - Allergic reactions - Liver damage - Rare cases of cancers like lymphoma - Rare brain infections like progressive multifocal leukoencephalopathy (PML) #### Important Considerations - Always inform your doctor about any other medications or supplements you are taking. - Regular check-ups are essential to monitor the effectiveness and safety of the treatment. - Biologic drugs can be expensive, but there are programs that may help cover the costs. Biologics can significantly improve the quality of life for those with moderate to severe Crohn’s disease by reducing symptoms and preventing flare-ups.