### What is Zeposia? Zeposia is a medication that was initially approved for treating multiple sclerosis (MS) in adults. In 2021, the FDA also approved its use for moderate to severe ulcerative colitis (UC) in adults. UC is a type of inflammatory bowel disease (IBD) that causes irritation, inflammation, and ulcers in the lining of the large intestine (colon). ### How Does Zeposia Work? The active ingredient in Zeposia is ozanimod, which is a sphingosine 1-phosphate receptor modulator. It works by preventing certain immune cells (lymphocytes) from leaving the lymph nodes, thereby reducing inflammation in the intestine. While the exact mechanism is not fully understood, it is believed that the reduced number of lymphocytes in the intestine helps alleviate UC symptoms. ### Dosage and Administration Zeposia comes in capsule form with dosages of 0.23 mg, 0.46 mg, and 0.92 mg. The dosage is gradually increased over the first few days of treatment. For those with mild or moderate liver problems, the dosage is adjusted accordingly. However, individuals with severe liver issues should avoid using Zeposia. ### Clinical Studies Clinical studies have shown that Zeposia is effective in treating UC. In a 10-week study, 18% of participants taking Zeposia achieved remission compared to 6% taking a placebo. In a longer 52-week study, 37% of those on Zeposia reached clinical remission compared to 19% on a placebo. ### Side Effects and Risks Common side effects include changes in liver function, upper respiratory tract infections, and headaches. Zeposia can also increase the risk of infections and cause changes in heart rate, especially during the first 8 days of treatment. It is important to monitor liver function and heart rate before starting the medication. ### Drug Interactions Zeposia can interact with several other medications, including CYP2C8 inhibitors and inducers, MAOIs, and live vaccines. Always consult your healthcare provider about any other medications you are taking. ### Cost and Support Zeposia requires a prescription and may be considered a specialty drug. Financial support services, including copay cards, are available to help with medication costs. Check with your insurance company and local pharmacy for more details.