### What is Mepolizumab (Nucala)? Mepolizumab, sold under the brand name Nucala, is a medication primarily used to treat severe asthma and certain other inflammatory conditions. It works by reducing the number of eosinophils, a type of white blood cell that can cause inflammation. ### How is it Used? Mepolizumab is administered as an injection. Adults typically receive a 100-milligram shot every 4 weeks, while children under 11 may receive a 40-milligram shot. The injection can be given in the arm, abdomen, or thigh. Initially, a healthcare provider will administer the injection, but you may be able to do it yourself at home after proper training. ### What to Expect? Common side effects include irritation, redness, or swelling at the injection site. Other possible side effects are headaches, back pain, and fatigue. Serious allergic reactions are rare but require immediate medical attention. ### Safety Warnings Mepolizumab should be used in addition to other asthma treatments like corticosteroids and inhalers. It is not a replacement for these medications. Inform your doctor if you have had shingles or parasitic infections, as the drug may weaken your immune response. Pregnant or breastfeeding women should consult their doctor before starting treatment. ### Effectiveness Clinical trials have shown that mepolizumab can significantly reduce the number of severe asthma attacks. It works by binding to a protein that produces eosinophils, thereby reducing their numbers and preventing inflammation. ### Conclusion Mepolizumab is a valuable medication for managing severe asthma and other inflammatory conditions. Always follow your doctor's instructions and report any side effects or concerns.