When dealing with skin conditions like atopic dermatitis (AD), your dermatologist will first assess the severity of your symptoms. They will look at how much of your body is affected and the intensity of symptoms like redness, discoloration, dryness, and itchiness. If topical treatments like steroid creams, calcineurin inhibitors, or newer options like crisaborole (Eucrisa) and JAK inhibitors don't control your symptoms, it might be time to consider more extensive treatments. Phototherapy is an option for larger affected areas or stubborn patches. For severe cases, systemic treatments like cyclosporine, methotrexate, or biologics such as dupilumab (Dupixent) and tralokinumab-ldrm (Adbry) might be recommended. These treatments work throughout the body to reduce inflammation and improve skin condition. The choice of treatment depends on the severity of your symptoms, how they affect your daily life, and how well you respond to initial treatments.