Many people wonder if vitamins, minerals, or other natural substances can affect mood disorders or even treat depression. While some products claim to enhance well-being, scientific evidence is often lacking. In the U.S., the FDA does not regulate these substances as strictly as drugs, making it crucial to approach them cautiously. Vitamin deficiencies are rare in developed countries but can cause mood issues when they occur. Deficiencies in B vitamins like thiamine, niacin, B6, or B12 can lead to depression or anxiety. Folic acid deficiency can also affect mood and mental function. If a vitamin deficiency is suspected, it should be addressed with supplementation. Chromium, a trace element, has shown some promise in treating depression, particularly in people with diabetes. However, more large-scale studies are needed. Always consult a doctor before trying new supplements, especially if you have severe or persistent depression.