Many women gain weight, especially around the belly, during menopause. A study using data from the Women’s Health Initiative found that medications often prescribed during this time, such as antidepressants, beta-blockers, and insulin, can make this weight gain worse. These medications are often given for depression, anxiety, high blood pressure, and diabetes. The study showed that women taking these medications had a greater increase in BMI and waist size. The biggest increases were seen in those taking antidepressants or insulin. Taking more than one of these medications made the weight gain even worse. Women from Black, Indigenous, and People of Color (BIPOC) communities were more affected than white women. This is due to a mix of biological, genetic, economic, social, and stress-related factors. Menopause is also a time when women are more likely to develop high blood pressure and mood disorders, leading to more prescriptions for these medications. Weight gain in midlife can also lead to insulin resistance and type 2 diabetes. To manage weight while taking these medications, women should talk to their doctors about the side effects and consider lifestyle changes like a healthy diet, regular exercise, and good sleep. Doctors should be aware of which medications cause weight gain and work with their patients to find the best treatment plan.