### How Zepbound Helps with Weight Loss Zepbound (tirzepatide) is a prescription medicine designed to help adults with excess weight or obesity lose weight, especially those with conditions like type 2 diabetes, high blood pressure, and heart disease. Approved by the FDA in 2023, Zepbound is injected once a week and works best when combined with a low-calorie diet and regular physical activity. #### How It Works Zepbound contains tirzepatide, which activates two proteins, GIP and GLP-1, that help your body produce insulin and control appetite. These proteins are part of a group of hormones called incretins, naturally produced by your gut when you eat. GLP-1 also helps you feel full faster and stay full longer, reducing your overall food intake. #### Clinical Studies Two major studies, SURMOUNT-1 and SURMOUNT-2, tested Zepbound's effectiveness. SURMOUNT-1 involved people without diabetes, while SURMOUNT-2 included those with type 2 diabetes. Both studies showed that participants who took Zepbound lost significantly more weight than those who took a placebo. #### Side Effects Common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, and indigestion. Serious side effects can include gallbladder problems, vision changes, and mood changes. It's important to stay hydrated and inform your healthcare provider of any other medications you're taking. #### Important Considerations Zepbound is not suitable for everyone. People with a history of certain thyroid cancers or multiple endocrine neoplasia syndrome type 2 should not use it. Always consult your healthcare provider before starting Zepbound, and follow their instructions closely for the best results.