Metformin, also known by brand names like Glucophage, is primarily used to manage high blood sugar in people with type 2 diabetes. It works by reducing the amount of glucose produced by the liver and increasing insulin absorption by muscle tissue. This medication has been around since 1995 and is considered the first-line treatment for type 2 diabetes due to its effectiveness and affordability. Recent studies suggest that metformin may offer benefits beyond diabetes management. For instance, research has indicated that metformin might reduce the risk of severe complications and death from COVID-19 in people with type 2 diabetes. One study found that the death rate for participants taking metformin was significantly lower compared to those who did not take the medication. Additionally, metformin has shown promise in reducing the incidence of long COVID when used as an early outpatient treatment. Beyond its potential role in COVID-19 treatment, metformin is being explored for other health benefits. Some studies suggest it may help with weight loss, particularly in people who are overweight or obese but do not have diabetes. It has also been linked to improved outcomes in conditions like polycystic ovarian syndrome (PCOS), osteoarthritis, and even Alzheimer's disease. While the FDA has only approved metformin for type 2 diabetes, its off-label uses are expanding as research continues to uncover new potential benefits. However, it's important to consult a healthcare provider before considering metformin for any off-label use.