Numbness in your toes can be caused by various factors, some serious and some not so serious. Here are a few potential causes: 1. **Diabetic Neuropathy**: High sugar and fats in your blood from diabetes can damage nerves, leading to peripheral neuropathy. This condition affects the feet and legs and can cause numbness. Other signs of diabetes may also be present. 2. **Morton's Neuroma**: This is a thickening of the tissue around a nerve leading to the toes, causing pain and numbness. It can be worsened by certain activities or shoes. Treatment includes changing footwear, using shoe inserts, and possibly corticosteroid shots. 3. **Metatarsalgia**: Pain in the ball of the foot that can come with numbness or tingling in the toes. Causes include foot shape, overwork, and being overweight. Treatment involves rest, ice, and changing shoes. 4. **Raynaud's Phenomenon**: Cold weather or stress can slow blood flow to the extremities, causing numbness and color changes in the toes. There are primary and secondary types, with secondary linked to autoimmune diseases. 5. **Guillain-Barre Syndrome**: An immune system disorder that damages the covering around your nerves, causing numbness. It is a rare but serious condition that requires emergency help. If you experience persistent numbness in your toes, it is important to consult a doctor to determine the underlying cause and appropriate treatment.