High cholesterol can increase the risk of heart disease, heart attacks, and strokes. To lower cholesterol, start with heart-healthy lifestyle changes such as a balanced diet, regular exercise, and weight loss. If these changes are not enough, medications like statins may be prescribed. Statins reduce cholesterol production in the liver and can lower the risk of heart attacks and strokes. Other medications include ezetimibe, bile acid-binding drugs, fibrates, niacin, omega-3 fatty acids, PSCK9 inhibitors, ACL inhibitors, and SiRNA therapy. Regular checkups with your doctor are important to monitor progress and adjust treatment as needed. Lifestyle changes and medications together can effectively manage high cholesterol.