### Zepbound: A New Drug for Weight Management The FDA has recently approved a new injection drug called Zepbound for chronic weight management. This drug is intended for adults who are either obese or overweight and have at least one weight-related condition, such as high blood pressure or high cholesterol. Zepbound is to be used in conjunction with a lower-calorie diet and increased physical activity. #### How Does Zepbound Work? Zepbound contains the active ingredient tirzepatide, which is already approved under the name Mounjaro for improving blood sugar levels in adults with type 2 diabetes. Tirzepatide works by activating receptors of hormones secreted from the intestine, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones help to reduce appetite and food intake, making it easier for individuals to manage their weight. #### Dosage and Administration Zepbound is administered by injection under the skin once a week. The dosage is gradually increased over a period of four to twenty weeks to reach the target dosages of 5 mg, 10 mg, or 15 mg once weekly. The maximum dosage is 15 mg per week. #### Clinical Trials and Efficacy The efficacy of Zepbound was tested in two randomized, double-blind, placebo-controlled trials. These trials demonstrated that Zepbound is effective in helping individuals manage their weight when used alongside diet and exercise. #### Potential Side Effects Like all medications, Zepbound comes with potential side effects. Common side effects include nausea, diarrhea, vomiting, constipation, abdominal discomfort, and pain. It is important to consult with a healthcare provider to understand the risks and benefits of using this medication. #### Importance of Weight Management Obesity and overweight are serious conditions that can lead to some of the leading causes of death, such as heart disease, stroke, and diabetes. Losing 5% to 10% of body weight through proper diet and exercise can significantly lower the risk of cardiovascular diseases. The approval of Zepbound addresses an unmet medical need, especially given the increasing rates of obesity and overweight in the United States.