In May 2020, the FDA recommended that some makers of metformin extended release remove some of their tablets from the U.S. market due to an unacceptable level of a probable carcinogen. If you take this drug, consult your healthcare provider. They will advise whether you should continue or need a new prescription. Generally, following your healthcare provider’s advice minimizes risks when switching diabetes medications. Switching from brand name to generic usually poses no risk, but switching medication classes may affect blood sugar levels. Monitor your blood sugar closely after switching. Side effects vary by medication. Metformin can cause bloating and gas, while glyburide may cause low blood sugar, headache, nausea, and dizziness. Sitagliptin can cause body aches, fever, cough, and a stuffy or runny nose. SGLT2 inhibitors like canagliflozin may increase genital infections and frequent urination. Rosiglitazone may cause body aches, sore throat, fever, and rarely, heart failure. Consult your doctor and pharmacist about your medication and its side effects. Mild side effects often fade as your body adjusts. If you experience signs of low blood sugar, check your levels immediately. If low, consume 15 grams of fast-acting carbs and recheck in 15 minutes. Serious side effects like nausea, vomiting, difficulty breathing, or swelling require emergency medical attention. Maintaining a healthy diet and exercise plan can reduce the amount of medication needed. Always take medications as directed and opt for generics if available. If brand medications are necessary, ask your doctor for preferred brands covered by your insurance. Manufacturers may offer discount cards for newer brands. Consult your doctor or pharmacist for options. Early on, you may notice more energy and fewer bathroom trips. Blood sugars should fall below 130 mg/dL before breakfast and below 180 mg/dL two hours after meals. After a few months, your A1C should drop below seven. Pharmacists can assist by checking blood pressure, ordering tests, and performing screenings. They can also conduct blood glucose and A1C testing. Talking to a pharmacist about managing diabetes is usually free, though additional services may incur costs covered by insurance. Alan Carter, PharmD, has extensive experience in diabetes medication evaluation and has authored 17 peer-reviewed medical publications.