### Tirzepatide and Semaglutide for Weight Management in Type 2 Diabetes Tirzepatide and semaglutide are medications commonly used to manage type 2 diabetes and are also prescribed off-label for weight management. Both drugs help reduce hunger by mimicking hormones that signal fullness to the brain. #### Semaglutide - **Brand Names**: Ozempic, Wegovy, Rybelsus - **FDA Approval**: Approved for type 2 diabetes; Wegovy is also approved for weight management - **Mechanism**: GLP-1 receptor agonist, mimics the GLP-1 hormone - **Administration**: Available in oral tablets and injections #### Tirzepatide - **Brand Name**: Mounjaro - **FDA Approval**: Approved for type 2 diabetes; off-label for weight management - **Mechanism**: Both GLP-1 and GIP receptor agonist, mimics GLP-1 and GIP hormones - **Administration**: Available only as an injection #### Effectiveness Recent studies suggest that tirzepatide may result in greater weight loss compared to semaglutide. However, more research is needed to confirm these findings, especially for people without diabetes. #### Side Effects Both medications have similar side effects, including moderate and severe reactions. They also carry a boxed warning for the risk of thyroid C-cell tumors. #### Conclusion While tirzepatide may potentially be more effective, it's too early to make definitive conclusions. Consult your doctor for the best guidance on these medications and their suitability for your weight management needs.