### What is Metformin and How Does It Work? Metformin is a medication commonly used to treat type 2 diabetes. It helps lower blood sugar levels by reducing the amount of glucose produced by the liver and improving the body's sensitivity to insulin. This means that insulin can work more effectively to help muscles use glucose for energy. ### Metformin and Weight Loss One of the side effects of metformin is weight loss. Although it was not originally designed for this purpose, studies have shown that it can help people lose weight. The exact mechanism is not fully understood, but it may involve changes in appetite, gut microbiome, and metabolic processes. Some people experience gastrointestinal side effects like nausea and diarrhea, which can also reduce food intake and lead to weight loss. ### Is Long-Term Weight Loss Possible? While metformin can lead to some weight loss, the amount is usually modest. On average, people may lose about six pounds after one year of taking the drug. It's important to combine metformin with a healthy diet and regular exercise for more significant and sustainable weight loss. ### Can People Without Diabetes Take Metformin? Metformin is sometimes used off-label for weight management in people without type 2 diabetes. However, it is not FDA-approved for this purpose and should only be taken under medical supervision. Healthy eating and lifestyle changes are still the most effective ways to lose weight. ### Conclusion Metformin can help with weight loss and improve insulin sensitivity, but it is not a magic solution. The most effective way to lose weight and manage type 2 diabetes is through a combination of medication, healthy eating, and regular physical activity.