### Dr. Jesse Roth's Contributions to Diabetes Research Dr. Jesse Roth is a significant figure in diabetes research, known for his groundbreaking work over the past five decades. His research has fundamentally changed how we understand and treat diabetes. **Key Contributions:** 1. **Insulin Receptors Discovery:** Roth's work hastened the discovery of insulin receptors and their molecular interactions within the body. This was a major breakthrough as it revealed that insulin receptors are not just in muscles and fat but throughout the entire body, including the brain. 2. **Understanding Insulin's Role:** He discovered that insulin itself does nothing without its receptors, which was a pivotal moment in diabetes research. This led to a deeper understanding of how insulin and its receptors work together, and how they function differently in different people. 3. **Multiple Types of Diabetes:** Roth's findings contributed to the realization that diabetes is not just one or two diseases but a portfolio of diseases, each requiring unique research and treatment approaches. 4. **Improved Treatments:** His research has led to more precise treatments for diabetes, such as SGLT2 drugs that help the body flush glucose through urine, benefiting people with type 2 diabetes and sometimes those with type 1. 5. **Ongoing Research:** Roth continues to explore new areas, such as the role of insulin receptors in the brain and the nervous system, and he remains optimistic about finding a cure for type 1 and type 2 diabetes. 6. **Combating Racial Disparities:** Roth is also passionate about addressing racial disparities in diabetes treatment, advocating for more accessible healthcare in the United States. Dr. Roth's work has not only advanced scientific understanding but also improved the lives of many people living with diabetes. His ongoing research and dedication continue to inspire hope for future breakthroughs.