### The Impact of Metformin on Age-Related Macular Degeneration A recent study published in the February issue of the journal Retina has found that people who take the diabetes drug metformin have a slightly lower risk of developing age-related macular degeneration (AMD). Specifically, the study found that metformin users have a 5% lower risk of developing this eye disorder. Age-related macular degeneration is a condition that affects the central portion of the retina, known as the macula, which is responsible for sharp, central vision. Over time, the macula can wear down, leading to serious and permanent vision loss, particularly in people over the age of 50. AMD is the leading cause of significant vision loss in older adults. The study involved more than 85,000 patients aged 55 or older who were recently diagnosed with AMD, as well as another 85,000-plus patients who did not have the disease. Among these participants, a subgroup of more than 22,000 patients also had diabetes. The findings revealed that among those with diabetes, metformin use was associated with an 8% reduction in the risk of developing AMD. This research suggests that metformin, a common medication used to manage diabetes, may have additional benefits in reducing the risk of age-related macular degeneration. However, further studies are needed to fully understand the mechanisms behind this protective effect and to confirm these findings in larger and more diverse populations.