Why does weight loss reverse type 2 diabetes for some people but not for others?

### Can Weight Loss Reverse Type 2 Diabetes? For some people with type 2 diabetes, losing weight can help control the disease and reduce the risk of other health problems. Research from Newcastle University in the UK has shown that significant weight loss can lead to remission of type 2 diabetes, where most or all signs and symptoms disappear. Dr. Roy Taylor and his team found that people with type 2 diabetes have high levels of fat in their blood, pancreas, and liver. After following an intensive weight loss program, participants were able to reduce these fat levels. As the fats decreased, some individuals experienced improved functioning of their pancreatic beta cells, which store and release insulin to control blood sugar levels. The ability of these cells to recover determines the likelihood of regaining normal glucose control. In a study published in 2017, about 46% of 149 individuals with type 2 diabetes who followed a weight loss program achieved remission. Participants consumed about 825 calories per day in liquid form for three to five months, then switched to less extreme diets. Results improved with the number of pounds lost: 86% of those who lost more than 33 pounds achieved remission, while 57% of those who lost 22 to 33 pounds reached that goal. However, not everyone responded to the weight loss program. Researchers found that people who had lived with diabetes for a longer time were less likely to restart normal insulin production. Those who had diabetes for an average of 3.8 years could not correct their condition through weight loss, while those who had it for an average of 2.7 years were able to regain normal blood sugar control. Dr. Joseph S. Galati, a hepatologist, recommends weight loss for diabetes control and emphasizes portion control, avoiding processed foods, and eating fresh vegetables, fruits, lean meat, poultry, and fish. Regular exercise should also be part of the program. He advises patients to first target a weight loss goal of 10%, then aim for increments of 5% to 7% over 6 to 12 months. He reminds patients that weight loss is a marathon, not a sprint, and requires patience and methodical effort.