Testosterone is a hormone that helps men maintain muscle, bone health, libido, and sexual function. Starting in their mid-30s, men lose an average of just under 2% of testosterone each year. This decline can eventually lead to low testosterone levels, affecting 1 in 5 men in their 60s. Testosterone Replacement Treatment (TRT) aims to boost these low levels. TRT has seen fluctuating popularity over the years. From 2001 to 2013, prescriptions increased dramatically due to marketing claims that it could restore energy, focus, and sexual function. However, the number of men using TRT dropped significantly after studies highlighted potential risks, including heart health issues. In 2014, the FDA required warning labels on TRT prescriptions about increased risks of heart attack and stroke. Some studies linked TRT to dangerous blood clots, but more recent research hasn't confirmed these risks and even suggests potential benefits like diabetes protection. Despite this, the American College of Physicians noted in 2020 that TRT offers limited benefits, mainly slight improvements in sexual function. There are mixed results regarding other benefits such as reduced fatigue. Men with very low testosterone levels face higher risks of heart disease, osteoporosis, and other health issues if untreated. Therefore, it's important to discuss the benefits and risks with a doctor. Low testosterone symptoms can also result from other health issues. If starting TRT, improvements should be noticeable within six months; otherwise, discontinuation may be necessary. TRT can reduce sperm production and affect fertility, although fertility usually returns after stopping TRT. Weight loss and exercise may naturally boost testosterone levels without medication.