Boniva is a prescription drug used to treat osteoporosis after menopause. It helps strengthen bones and reduce the risk of fractures. Boniva comes in tablet form and is taken once a month. Common side effects include mild gastrointestinal discomfort, headache, and muscle, bone, or joint pain. Serious side effects may include esophagus inflammation, teeth and jaw problems, and thigh fractures. Seek immediate medical attention if serious side effects occur. To reduce the risk of side effects, take the medication as prescribed and have regular dental check-ups.