Nighttime heartburn affects many people who suffer from regular heartburn and acid reflux. To prevent nighttime heartburn, consider these tips: 1. Sleep on your left side to reduce symptoms. 2. Lose some weight, as even a small amount can help. 3. Elevate your upper body while sleeping. 4. Wear loose-fitting clothes to avoid pressure on your stomach. 5. Avoid foods and drinks that trigger heartburn, such as alcohol, caffeine, chocolate, peppermint, garlic, onions, milk, fatty and spicy foods, and acidic foods like citrus and tomatoes. 6. Don't eat large meals or late-night snacks; try to eat two to three hours before bedtime. 7. Relax when you eat and avoid rushing. 8. Stay upright after eating to prevent acid from creeping up your esophagus. 9. Wait a couple of hours after eating before exercising. 10. Chew gum to produce saliva, which can help wash acid down into your stomach. 11. Quit smoking, as it can irritate the GI tract and relax esophageal muscles. 12. Discuss with your doctor any medications you take that might cause heartburn. If lifestyle changes don't help, consult your doctor for further treatment options.