Coffee contains caffeine and various nutrients that can benefit people with lupus. The caffeine in coffee can make you feel more energized and focused, improve breathing, promote weight loss, and enhance cognitive function. However, it affects everyone differently. For some, it may cause stomach upset and heartburn. If you are taking prednisone, a common lupus medication, coffee could increase your risk of osteoporosis. Caffeine can also affect sleep, making lupus-related fatigue worse. Coffee helps by releasing anti-inflammatory proteins and regulating inflammatory responses. Studies show that daily caffeine intake between 154 mg to 377 mg lowers inflammation and reduces lupus disease activity. Caffeine interacts with the immune system, causing responses that can benefit lupus patients. Some studies indicate that drinking more coffee is linked to clinical remission from lupus. However, the benefits depend on the specific caffeine dose and usually exclude added sugar and cream. For Colombian lupus patients, daily coffee consumption is associated with a reduced risk of early onset and cardiovascular disease. Overall, coffee seems beneficial for reducing lupus activity, but its effects vary. Consult your doctor before increasing caffeine intake, and consider caffeine pills as an alternative if advised.