How to use dexamethasone to induce osteoporosis in mice?
Dexamethasone is a type of steroid medication that can suppress the formation of bone cells and increase the breakdown of bone cells, leading to osteoporosis. Researchers often use dexamethasone to induce osteoporosis in mice to study this condition. The specific method involves dissolving dexamethasone in saline solution and then administering it to the mice either through injection or orally over a period of time, usually several weeks to months. This results in a gradual decrease in bone density, causing symptoms of osteoporosis in the mice.