Ankylosing spondylitis (AS) primarily affects your spine, especially the lower back and hip joints. However, it can impact various other body parts. AS is an inflammatory disease linked to your immune system. Besides back pain, you should watch for symptoms in these areas: Eyes: AS can cause uveitis, an eye inflammation that may lead to vision loss if untreated. Bones: AS can weaken bones, leading to osteoporosis and fractures, particularly in the spine. This can cause a hunched posture and nerve damage. Digestive tract: Many people with AS experience gastrointestinal issues like stomach pain or diarrhea due to inflammation in the intestines. Skin: AS can cause skin rashes and is often associated with psoriasis. Heart: The inflammation from AS increases the risk of heart attack or stroke and can damage the aorta, leading to heart valve issues. Nerves: Rarely, AS can damage the cauda equina nerves at the spine's base, causing severe symptoms that need immediate attention. Lungs: AS may cause parts of the ribcage to fuse, leading to lung issues such as shortness of breath. Regular checkups and monitoring for new or worsening symptoms are crucial for managing AS effectively.