Lupus is a systemic disease that affects multiple systems, causing various complications throughout the body, including the kidneys, heart, lungs, eyes, and bones. In the kidneys, lupus nephritis is the most common complication, which can lead to permanent loss of kidney function and failure. Damage to the bone marrow can lower red and white blood cells and platelets, leading to blood-related disorders. For the heart, lupus can cause myocarditis or pericarditis; long-term inflammation can result in permanent heart damage. Bone-wise, long-term steroid use for lupus treatment can lead to osteoporosis, increasing the risk of fractures. In the lungs, lupus can cause pleurisy, leading to breathing difficulties and chest pain. For the eyes, lupus can cause dry eye, cataracts, and glaucoma. Lupus patients may also face risks of anxiety and depression.