Prolia (denosumab) is a prescription drug used to treat osteoporosis, a condition that causes bones to become weak and prone to fractures. Prolia is administered through injections and is suitable for certain adults with osteoporosis, including those receiving certain treatments for breast or prostate cancer. The active ingredient in Prolia is denosumab, a biologic medication. Prolia can cause some mild or serious side effects. Common mild side effects include joint pain and reactions at the injection site, such as redness or pain. Serious side effects, though rare, may include low blood calcium levels, jaw necrosis (death of jawbone tissue), and serious infections. If you experience any discomfort while using Prolia, contact your doctor immediately. Your doctor may advise you to stop using the medication or take other measures to manage these side effects. Regular communication with your doctor and following their advice can help you better manage osteoporosis and the side effects of the medication.