When non-small-cell lung cancer spreads to the bones, it can cause significant pain. There are several treatments available to alleviate this pain. Chemotherapy can shrink tumors, reducing bone damage and pain. Radiation therapy uses high-energy rays to kill cancer cells and strengthen bones, making them less likely to break. Bisphosphonates are drugs that slow bone loss and can relieve pain by preventing fractures. Denosumab, a monoclonal antibody, can also strengthen bones and prevent fractures. Pain relievers like NSAIDs (aspirin, ibuprofen), opioids (codeine, oxycodone), and medications like gabapentin can help manage bone pain. Additionally, surgical options like removing part of the tumor or stabilizing the bone with rods or screws can provide relief. Procedures like vertebroplasty can help with back pain by injecting cement into the spine to prevent bone collapse.