As you age, your bones tend to become weaker. This issue can be more pronounced if you have HIV (Human Immunodeficiency Virus). HIV not only increases the risk of fractures, but some anti-HIV medications can also accelerate bone loss. Bones are not entirely solid; they are living tissues made up of honeycomb-like structures filled with fluids. With aging, the body may not generate new bone quickly enough to replace the old bone, causing bones to become fragile. If bone loss is severe, doctors may diagnose osteoporosis. Lesser bone loss is called osteopenia. About half of people with HIV will develop osteoporosis or osteopenia, and they are twice as likely to break a bone compared to those without HIV. People with HIV are more likely to have risk factors for bone loss, such as smoking, drinking alcohol, using opioids, having low testosterone, and consuming less calcium and vitamin D. HIV itself may contribute to bone loss, with some studies showing a link between HIV and bone density reduction. Certain anti-HIV drugs, like tenofovir, can weaken bones. This problem is more pronounced as people with HIV age. Osteoporosis is often called a