People with exocrine pancreatic insufficiency (EPI) need pancreatic enzyme replacement therapy (PERT) to help their body digest food and absorb nutrients. Without these enzymes, they risk malnutrition, weight loss, and conditions like osteoporosis (weak bones) or anemia (low red blood cells). PERT provides the necessary enzymes that the pancreas isn’t making, improving digestion and nutrient absorption. PERT must be taken correctly with meals or snacks, and the dosage may vary based on individual needs. Side effects can occur but usually go away as the body adjusts. It’s important to follow your doctor’s instructions and stay in regular contact to manage your therapy effectively.